Biology 3593B Lecture Notes - Lecture 2: Drug Metabolism, Hypotension, Adme

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Pharmacokinetics: pharmacokinetics: the study of drug movement in the body, pharmacokinetics consists of 4 processes (adme) that the body does to the drug, absorption, distribution, metabolism, excretion. Rate of drug dissolution: dissolution: means dissolving in solution, drugs must dissolve before they can be absorbed, drugs with a fast rate of dissolution will have a faster onset of action than drugs with a slow dissolution rate. If the drug does not completely disintegrate or does not dissolve into solution, absorption is reduced. Bioavailability: bioavailability: the fraction of a dose of a drug that reaches the systemic circulation unchanged, bioavailability is influenced by, drug formulation (by which the drug is administered, route of administration, degree of metabolism in the liver. Sublingual administration: sublingual administration: involves placing a drug under the tongue, the venous (blood) drainage from the oral mucosa goes into the superior vena cava,

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