Biology 3597A/B Lecture Notes - Lecture 17: Transferase, Conformational Change, Insertion Sequence
24 Mar 2017
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Like transcription initiation is most complex and regulated. I(cid:374)itiator (cid:373)et trna is sy(cid:374)thesized a(cid:374)d it"s the o(cid:374)ly o(cid:374)e that starts i(cid:374) the p site. Ultimately goal of initiation is to get ribosome to initiator aug met. The initiator trna is different then average trna. The actual initiation is broken into 4 steps (5 if including charging trna) Each step is moving from 1 complex to another get bigger. All of initiation basically occurs with small subunit then large subunit comes in. Small subunit is where mrna is bound and where there is recognition of codon and anticodon of trna trna met aa (charged got met and gtp) and initiation factor. Eif eukaryotic initiation factor, later it becomes eef elongation factor. Ternary complex is basically charged trna and initiation factor this ternary binds small subunit. Now adds 2 initiation factors (4g, 4e)
