Biology 1001A Lecture Notes - Citric Acid Cycle, Maintenance Of An Organism, Hormesis

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Role of cytochrome oxidase in production of ros - Cytochrome oxidase takes the electrons in the etc and reduces o2 to make water. If cytochrome oxidase donated electrons one at a time, aerobic life would not exist as by adding one electron at a time, you would produce too many partially reduced o2 which is. However, cytochrome oxidase actually donates 4 electrons simultaneously; a complete reduction from o2 to h2o. Thus, cytochrome oxidase not a major source of ros because of this. Role of quinone pool in production of ros - Quinone pool is the most common site of ros production. The reason is that there is so much o2 competing with downstream electron that some of the electrons from the pool leak and the o2 is reduced by an electron creating superoxide. Sod1 would take superoxide and catalyze reaction to form h2o2 which is then broken down by catalase. How defects in mitochondrial function might lead to disease -

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