Biology 1001A Lecture Notes - Lecture 4: Spindle Apparatus, Sister Chromatids, Chromosome Segregation

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23 Mar 2014
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9. 1- the cycle of cell growth and division: an overview. In mitotic cell division, dna replication is followed by the equal separation (segregation) of the replicated dna molecules and their delivery to daughter cells. **kinetochore-a specialized structure consisting of proteins attached to a centromere that mediates the attachment and movement of chromosomes along the mitotic spindle. Spindle is fully formed and chromosomes, moved by the spindle microtubules, aligned at the metaphase plate the become: anaphase- spindle separates the sister chromatids and moves them to opposite spindle poles. At this point, chromosome segregation is complete: telophase- the chromosomes decondense and return to the extended state typical of interphase. 9. 2- the mitotic cell cycle: mitosis and interphase constitute the mitotic cell cycle. Each chromatid has a *kinetochore that attaches to spindle microtubules b. microfilaments just under the plasma membrane contracts, gradually separating the cytoplasm into two parts.

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