Biology 1001A Lecture Notes - Lecture 12: Heterozygote Advantage, Melanocortin 1 Receptor, Genotype Frequency
14 Dec 2015
School
Department
Course
Professor
Document Summary
Product rule still works to predict genotype frequencies, but allele frequencies not always 50/50. Random mating pp where mutations are rare enough to be ignored, in absence of immigration or emigration, and if there is no selection. Only is conditions are true = genetic equilibrium = no evolution. If conditions apply, then genotype frequencies can be made from predictable allele frequency f(a1a1) = p2 f(a1a2) = 2pq f(a2a2) = q2. Use observed phenotype or genotype frequency to calculate allele frequency (refer to table in tb) Genotype frequencies: 0. 45, 0. 5, 0. 05: use observed allele frequencies and probability to calculate expected genotype frequencies, compare observed vs expected numbers for each genotype: is the pop in hardy weinberg. Observed: 450 red, 500 pink, 50 white. To recognize evolution, we need to know what a non-evolving pop looks like. If genotype frequencies can be predicted from allele frequencies, pop is in hardy weinberg equilibrium (hwe) at this locus.
