Biology 1002B Lecture Notes - Lecture 19: Lung Cancer, Heritability, Embryogenesis
22 Mar 2017
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Document Summary
Segmentation genes are expressed rst in the nucleus of the zygote. Programmed cell death mechanism: executioner caspases are proteases that cleave speci c essential proteins. Leading to a controlled but irreversible biochemical cascades causing cell shrinkage, chromatin fragmentation and cell death. Bacterial plasmids can code for their own transfer. Integrated regulation of programmed cell death: hox genes regulate development, ecdysone, regulates the reaper mrna. Positive regulator turns on its own promoter, causing it to stay on: chromatin packaging/methylation, dna methylation can silence in two ways, methylation the dna -transcription factor can no longer bind, hdac-histone deacetylate reduce transcription. X-chromosome inactivation: hallmarks of cancer, ignore death signals, ignore signals to stop growing, invade other tissues, etc. In canada, men are at higher st ok cancer than women: 40% of women are expected to get cancer, 45% of men are expected to get cancer.
