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Lecture 11

Biology 1002B Lecture Notes - Lecture 11: Dna Polymerase Ii, Dna Polymerase I, Dna Polymerase

Course Code
BIOL 1002B
Patrick Mc Donald

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F e b 8 | 1
Biology 1202 B
Lecture Cycle 5 (Lecture 11)
DNA Structure, Replication, and Organization
Material Covered – DNA Replication and
DNA Replication
New strand assembled 5’ to 3’
- Template read 3’ to 5’
Hydrolysis of 2 phosphates
- Phosphodiester linkage elongates chain
Bacterial DNA Polymerase
Palm conserved between species
- Fingers and thumb di$er
Palm is the site of polymeriza&on
Sliding DNA Clamp – Keeps polymerase tethered to template
- Increases e.ciency
Initiation of DNA Replication
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