Biology 1002B Lecture Notes - Lecture 6: Dna Replication, Cytosine, Guanine

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Human genomes are filled with dna junk : despite articles; it has nothing to do with the makeup of humans. Dna replication = semi-conservative: proven in the meselson & stahl experiment, each of the 2 new daughter strands contain one strand from the parent dna. Dna polymerase adds to a free 3" hydroxyl (oh: the next nucleotide"s phosphate attaches to the 3" end at the oh. Every nucleotide in the known universe attaches to the 3" end. Replication bubble arises form two forks created at one origin : replication forks travel in both directions at the same time, creating a bubble. Chromosomes are replicated fast via multiple origins (firing off simultaneously, many bubbles at once) Chromatids are identical dna molecules attached at the centromere: the number of chromosomes does not change in the s phase, however the number of c doubles as dna is replicated during s-phase of the cell cycle.

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