Biology 1202B Lecture Notes - Lecture 15: Histone Deacetylase, Rna Interference, Xist (Gene)

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Gene must be expressed or not expressed in the correct tissue (special) and at the correct time (temporal). Gene expression is like music played by an orchestra: gene is present in dna but is it on or off , on gene is expressed and actively transcribed, off gene is not expressed and not actively transcribed. In different tissues and times this may change: gene is individually fine tuned, gene"s tuning is dynamic and aware of its surrounding. The lac operan is an example of transcriptional regulation demonstrating how genes are turned on and off. Operator a short segment to which a regulatory protein binds. Produce a large number of different types of cells. More complicated since nuclear dna is bound to histones, thus need chromatin remodeling to loosen histone dna interaction (acetylases add acetyle groups to histones) or slide nucleosomes away from gene"s promoter region. Remodeling is a crucial initial event because it opens the way for transcription to occur.

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