Biology 1202B Lecture Notes - Lecture 25: Personalized Medicine, Telomerase, Cell Damage
14 Apr 2019
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Genetic heterogeneity of cancers - single cell genome sequencing. Cancer genome atlas: database that contains info about different types of cancer. I. e. sequences, mrna expression levels: took tissue samples from people, genomic dna analysis of various types of cancer. Intertumoral heterogeneity: same type of breast cancer but various categories of it (different mutations in different people: within one tumor in one person they performed single cell genome sequencing. Cell damage normally occurs in the dna sequence, indogenous, through dna polymerase than repair enzymes, if it cant be fixed, p53, if it goes undetected, the mismatch causes apoptosis (knows there is a mutation just not sure where) In cancer cells, the cell does not apoptosis: cells have anti-apoptosis pathways, the third mutation is toward the cancerous state, the cells support proliferation (antiapoptosis) First thing they do is make sure telomerase is activated (binds to a transcription factor which activates begins the transcription for the telomerase gene.
