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Lecture 16

Lecture 16 – Blood and Oxygen Association Curves

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Biology 2601A/B
Graeme Taylor

LECTURE 16 – BLOOD AND OXYGEN ASSOCIATION CURVES Blood  The simplest way to move respiratory gases is by dissolution  Diffusion is metabolically free, random movement of molecules  Oxygen will move along a gradient in the blood to the active tissue where oxygen is being consumed  However, the quantities of gas that can be moved around in this way will be limited by the solubility of the gas concerned Blood must be Thicker than Water  Solubility of2O in water (especially warm salty water) not enough to provid2 O to active tissues  Many organisms use respiratory pigments to bind O2and transport it to tissues Respiratory Pigments  Air diffuses rapidly and easily into the blood across blood capillaries  Oxygen will enter blood system in solution, however respiratory pigment grabs onto oxygen – bound and no longer in solution  Partial pressure of oxygen in the blood decreases, and this allows more to diffuse across and more to bind to pigment  What it means to have a respiratory pigment? o Can not only extract a lot of oxygen out of water, but can transport a lot per unit volume as well  Can be in solution or enclosed in blood cells  Hematocrit o Centrifuge whole blood and measure proportion of ‘solids’ (cells) o A pretty good measure of blood oxygen carrying capacity in vertebrates  Components of a respiratory pigment o Heme group – contains metal, site at which oxygen is bound o Inside a single red blood cell, there are about 250 million oxygen binding sites Chlorocruorins (ChLs)  Green hemoglobins  Found in four polycheate families  Two important ones are the Serpulidae (Christmas tree worms) and the Sabellidae (feather duster worms) Hemerythrins  Sipunculida  Priapulida  Brachiopoda Hemoglobins  Most widely distributed respiratory pigment in the animal kingdom  Some traces are also found in the plant kingdom Hb Oxygen Association Curve  Full saturation – at the respiratory surface  Shape of association curve is sigmoid  Saturation is relatively easy to achieve  As partial pressure drops, oxygen is easily loaded (or unloaded) o Subway example – Yonge and Bloor is very packed, hard to get on but as you move through the
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