Biology 3316A/B Lecture Notes - Lecture 1: Cytochrome C, Proteasome, Cytosol
7 Mar 2018
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Apoptosis-lecture 1: apoptosis is a regulated cellular death/suicide, during apoptosis the cell will go through: Dna fragmentation: becomes phagocytosed by phagocytic cell. Slide 8+9: apoptosis pathways in c. elegans: when ced9 is bound to ced4 dimer, apoptosis can"t be triggered ced4"s apoptotic ability is inhibited, if egl(cid:883) binds to ced9, it will inhibit ced9 by taking ced4"s position. Slide 10: mammalian caspases: initiator caspases = 2,8,9 activate effector caspases, effector caspases = 3,6,7, caspases that are involved in inflammatory cytokine processing, c-aspases . Aspases = target polypeptides and cleave them at sights next to asparate acid: in healthy cells, caspases are in precursor form known as (cid:498)pro- caspases(cid:499) Slide 11: apoptotic caspases are activated by extrinsic or intrinsic death signals. Slide 14: bcl-2 family proteins: bh3 domain only proteins for pro apoptotic members bim, Puma, bad: bh3,2,1 domains pro apoptotic proteins bak and bax and bok, bh4,3,2,1 domains pro survival proteins bcl-2, bcl-xl.
