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BIOL 3338A (89)

Class Notes for Biology 3338A at Western University

Developmental Biology

Biology 3338A Lecture 3: Developmental Biology Section 3

Section 3 October 1, 2015 10:38 AM Cell signalling Eggs are asymmetric When the eggs divide, they all follow the same cleavage patterns. All the cells in the blastocoel have different determinants Lots of different ind...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture 2: Developmental Biology Section 2

Section 2 September 30, 2015 5:32 PM Transgenic and Chimeric mice Chimeric mouse: an animal made up of different things. A mouse thats made up of different cells; mixture of different cells; not its own cells Transgenic ...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 7: Archenteron, Spindle Apparatus, Mitosis

Section 5: - Cleavage: series of mitotic events that divide an egg cytoplasm into numerous nucleated cells called blastomeres. - Protostomes means your mouth comes first. - Deuterostomes mea...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 12: Primitive Streak, Germinal Disc, Hypoblast

3338 Lec 12 -chick gastrulation is very different from frog gastrulation except identical dorsal organizer concept -chick gastrulation is more similar to human gastrulation with primitive streak formation -all bird e...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 15: Chordin, Lithium Chloride, Gsk-3

3338 Lec 15 REVIEW -beta-catenin required to activate gsc -LiCl treatment increases gsc because LiCl inhibits GSK3 allowing beta-catenin to be active in all cells more gsc in dorsalized embryo -UV treatment decr...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 7: Spindle Apparatus, Actomyosin Ring, Cytochalasin

3338 Lec 7 -cleavage divides maternal determinants in egg cytoplasm -cleavage patterns are conserved within species -BUT mammals have unique cleavage patterns ie. not as conserved within species -fertilized mammal eg...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 20: Neural Crest, Rho Family Of Gtpases, Pax3

3338 Lec 20 -gastrulation and neurulation patterns/movements occur differently in different animals -BUT some principles conserved whether frog, chick or mouse embryo -dorsal mesoderm causes neurulation -neural tu...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture 19: 3338 Lec 19

3338 Lec 19 neuropores = open ends on anterior and posterior sides of closed neural tube neural tube closes to resemble straw with two open ends ie. neuropores need to close neuropores top shows mouse embryo where neural t...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 23: Sonic Hedgehog, Limb Bud, Zone Of Polarizing Activity

3338 Lec 23 -ZPA due to Shh gradient -posterior = high Shh -anterior = low Shh -top shows fingers numbered with 1 anterior-most (thumb) and then down to 5 posterior-most (little finger) -different levels of BMP r...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 14: Beta-Catenin, Regional Differentiation, Gsk-3

3338 Lec 14 -inject GSK3 inhibitor beta-catenin saved in injection site = form another dorsal organizer = embryo with two dorsal axes -lithium chloride inhibits GSK3 -dorsalized embryo = inject LiCl into embryo = inh...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 5: Fibroblast Growth Factor Receptor, Paracrine Signalling, Optic Vesicle

3338 Lec 5 -can tell from pigmentation that frog eggs are asymmetrical -different maternal determinants localized in different areas -external fertilization = male drops sperm and squeezes female to drop eggs -get ...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 9: Basal Lamina, Blastocoel, Blastula

3338 Lec 9 a) fate map of zygote with animal and vegetal sides after initial cleavages b) different blastomeres in three germ layers in different regions containing different maternal determinants c) blastula continues ...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 16: Bone Morphogenetic Protein 4, Follistatin, Chordin

3338 Lec 16 -specifically, BMP4 induces epidermis NOTE: BMP not necessarily bone-related -top shows MBT with gsc on dorsal and BMP on ventral secreted to all ectoderm -thus all ectoderm turns into epidermis unless B...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 2: Germ Plasm, Central Dogma Of Molecular Biology, Cell Adhesion Molecule

3338 Lec 2 -in Weismann’s time, knew that sperm cell and egg cell together contained everything needed to make embryo ie. contained germ plasm -only germ cells had ‘germ plasm’ -rest of cells had ‘determinants’ = ...

Biology
Biology 3338A
Sashko Damjanovski
Biology 3338A Lecture Notes - Lecture 4: Northern Blot, Southern Blot, Syncytium

3338 Lec 4 -to ensure selected mice are homozygous recessive, do Southern Blot -isolate genomic DNA and put through gel smaller DNA travels further down while bigger DNA does not go far from the top -BMP probe is radioa...

Biology
Biology 3338A
Sashko Damjanovski
Permachart - Marketing Reference Guide: Extensor Carpi Ulnaris Muscle, Flexor Pollicis Longus Muscle, Abductor Digiti Minimi Muscle Of Hand

perm ach artsMT T rigger Points II: Extremities T rigger Points II: Extremities ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Sacral Plexus, Lumbar Plexus, Sympathetic Ganglion

pe rm a ch ar ts MT Spinal Cord 2nd EDITION Figure ...

ANAT - Anatomy
ANAT 14
All Professors
Multicellular Biology - Reference Guides

This Guide is the progressive companion to the Cellular Biology title. The complexities of human physiology are made much clearer through the bright graphics and intelligently coordinated text boxes and glossaries that are...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Levator Veli Palatini, Orbicularis Oculi Muscle, Scalene Muscles

Muscular System: pe rm ac ha rts MT Head & Torso 2nd EDITION ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Heart Valve, Inferior Vena Cava, Pulmonary Valve

permacharts TM Cardiovascular Physiology 2nd EDITION HEART STRUCTURE & FUNCTION ...

ANAT - Anatomy
ANAT 14
All Professors
ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Meiosis, Nuclear Membrane, Nuclear Pore

l e a r n • r e f e r e n c e • r e v i e w permacharts TM CCellular Biology BIOLOGY BASICS C...

ANAT - Anatomy
ANAT 14
All Professors
Cellular Respiration - Reference Guides

The specific aspects of cellular respiration are explained in this helpful Guide. The fundamental processes such as the electron transport chain, proton pumps, ATP synthetase, and glycolysis are each described with helpful...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Submandibular Duct, Parotid Duct, Palatine Tonsil

pe rm a ch a rtsMT DDigestive System 2nd EDITION Fi...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Antigen-Presenting Cell, Memory T Cell, Clonal Deletion

permacharts TM IImmunology 2nd EDITION G ENERAL INFORMATION - AN OVERVIEW ...

ANAT - Anatomy
ANAT 14
All Professors
Permachart - Marketing Reference Guide: Superior Frontal Sulcus, Inferior Parietal Lobule, Superior Frontal Gyrus

p erm ac hartsMT Brain 2nd EDITION FIGURE 1: GROSS ANATOMY (LATERAL VIEW) ...

ANAT - Anatomy
ANAT 173
All Professors
Permachart - Marketing Reference Guide: Superficial Palmar Arch, Costocervical Trunk, Thyrocervical Trunk

p erm a ch ar tsMT CCirculatory System 2nd EDITION Figure...

Biology
BI 361
All Professors

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