Biology 3660A/B Lecture Notes - Lecture 21: Kisspeptin, Arntl, Melanopsin

• School: Western University
• Department: Biology
• Course: Biology 3660A/B
• Professor: Brent Sinclair

Document Summary

Model species: phodopus sungorus hamsters long day breeder, semi domesticated easily wrangled in the lab, short gestation periods, offspring need to grow enough to survive winter, ovis aries sheep short day breeder, take advantage of new growth spring, long gestation, domesticated (with wild and feral counterparts, economically important. Siberian hamster model (cid:224) long day breeder: semi domesticated, some what easy to handle, summer slim and brown, winter white coat, fat and fur, daily torpor in the summer (cid:224) more mass in the summer than winter, much darker in the summer, in the summer they are less cold tolerant. Gene transcription: clock gene transcription (cid:224) produces clock protein, bmal1 gene (cid:224) produces bmal1 protein, clock gene product circulates in blood stream (cid:224) transcription factor, produces period (per) and cytochrome (cyr, per + cyr inhibit clock+bmal1, breakdown in time dependent manner controls clock genes, per and cry inhibits bmal1+clock, bmal1 produces rev erba which is negative feedback for bmal1.