Chemistry 2223B Lecture Notes - Postmarketing Surveillance, Tetrahydrofolic Acid, Pteridine
17 Apr 2014
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Chemistry 2223b (cid:121) winter 2013 14 (cid:121) western university. Role of chemistry in pharmaceutical drugs (cid:120) in this chapter, we will discuss the importance of chemists and chemistry in the discovery and development of pharmaceutical drugs. This may require research on the fundamentals of disease or biological processes, and on the action of existing drugs. Drugs (cid:121) 3 (cid:120) there are four popular methods used to find new candidates. (cid:120) method 1: extraction from natural sources. Taxol (cid:120) method 2: structure-activity relationship studies (sars) are used to make better compounds from those identified serendipitously or by purposeful searching: sars determine the effect of structural changes to the molecule on its activity. Assays are typically performed in microwell plates using robotic instrumentation but chemists and biochemists are still needed to interpret the results. Drugs (cid:121) 5 (cid:120) regardless of the method used, the best candidates (typically 1-5 out of every: are patented and subjected to preclinical evaluation.
