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Topic_6-_Enzyme_Catalysis_(Sept_27)[1].docx

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Department
Chemistry
Course
Chemistry 1027A/B
Professor
Terry Biggs
Semester
Fall

Description
Biochemistry 2280 Enzyme CatalysisLecture 7EnzymesBiological catalystsPerform nearly all chem transformations in cellsAccelerate but are unchanged by a rxnMost enzymes are proteinName often ends in ase eg ProteaseOften extremely specificAct on only 1 or a few ligands called substratesSubstrate the molecule on which an enzyme actsEnzymes carry out a limited number of chem rxns because it is very specificTypes of chem rxns carried out by enzymesHydrolytic cleavage using waterCondensation connect molecules togetherIsomerization rearrange bondsOxidationreduction gain or loss of electronsGroup transfer transfer chemical groupWhat did she say about these Did she say know what these rxns mean but not specific examples of themActive site of enzymesPart of the enzyme where the rxn takes placeSmall part of the enzyme surface 5 or lessOften a cleft or crevice between 2 domains or subunitsSubstrate binds in the active siteMultiple weak bondsDissociates from enzymeEnzymeSubstrateEnzyme substrate complexEnzyme product complexEnzymeProd
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