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Chemistry 1027A/B
Terry Biggs

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Biochemistry 2280 Protein FunctionLecture 6Almost everything that happens in a cellSeveral hundred thousand in our bodiesProtein topography surfaceProtein surfaces have a huge variety of shapes and charge distributionShapes are related to their functionDue to variety of amino acid side chains and many arrangements of secondary and tertiary structureLigandbinding proteinsLigand a molecule that can bind to a proteinMany proteins contain sites to which ligands specifically bind to form a complex w the proteinBinding occurs by multiple weak forces leads to extreme specificityExample of ligandbinding protein HemoglobinHemoglobin is a tetramer 4 individual polypeptide subunitsA ligand can generate a conformational changeLigand bindingDissociation ConstantKd dissociation constant a measure of the strength or affinity of an interactionHigh affinitytight bindingsmall KdTight binding requires the cooperative formation of many weak bondsUnits are moles molesL MKds in biological situations range from femtomolar very high affinity to millimolar low affinityAn equilibrium constant For a protein P binding ligand LPL are the reactantsPL is the proteinligand complexProtein complexesGroup of proteins that work together to perform some job within the cellEx ribosomeprotein synthesisSpecific complex of more than 50 proteinRNAsEx proteasomeprotein degradation ATP requiredSpecific complex of 20 proteinsEach protein within the complex must recognize and bind to others in the complex thus assembling into a supramolecular structureCase study collagenMost common protein in animalsExtracellular forms very long and strong fibers or sheetsFunctions to connect and strengthen tissues provides structure and mechanical strength to tissuesBone matrix tendons and connective tissueFoodFamily of proteinsCharacteristic structure triple helicalTriple helix is composed of mainly proline hydroxyproline and glycineMany genetic diseases arise due to defectsEx Osteogensis imperfecta
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