Chemistry 2223B Lecture 3: Topic 3- Amino Acids 2
8 Feb 2020
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S t r u c t u r e proteins are naturally occurring completely. A-as hydrolyzed , they are broken down into. Aa monomers are a- aas (amino group attached to cy to carboxyl group) except pro are to amines. " " a fri. t. r: iii. wit. Hydrolysis can also be done in basic conditions with oh -0 as. Most aas are l- aas (usually corresponding to. Cis configuration (side chain is - (h2sh) is r an s configuration) Not ionized side chains but have polar groups (e. g . Acid - base properties for any weak acid : Ha t hao f a-0 t hz0 ka =[a ]chg. " not pka of cooh = 2 is. Hz ewg endpoint (all deprotonated) pka2 ph t p" pka , pkaa. Low ph : the protonation states given ( nhs , cooh ) fully protonated pka values. Neutral ph : ammonium group protonated ,
