Chemistry 3393A/B Lecture Notes - Lecture 10: Phenyl Group, Amine, Epoxide
15 Mar 2017
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Topic j: metabolic studies and chemical & process development. This topic covers the following sections of the textbook: After studying this chapter, you should be able to do the following textbook questions: And these multiple-choice questio(cid:374)s o(cid:374) the te(cid:454)tbook"s (cid:449)ebsite (http://global. oup. com/uk/orc/chemistry/patrick5e/): chapter 15: 2 12. Follow its conversion into a different molecule. Isotopes are hard to work with because they are constantly decaying. Acetaminophen: of the carbon that (cid:449)o(cid:374)"t be re(cid:373)o(cid:448)ed or destro(cid:455)ed, (isotope gas to metabolite). Hydrogen is harder to tag because of hydrogen exchange. Tagging needs to be done in a location where there is stability in place. This is to prevent degradation of the radioactive isotope. Once absorbed, the radioactivity is measured from urine (urinalysis), fecal analysis and blood samples. Have an idea of what the metabolite will be so make them in the lab and compare the fragmentation patterns of the known to patterns of metabolites you get.
