History 2186A/B Lecture 5: Polymorphism in the gene FK506 binding protein 5
8 Feb 2016
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Document Summary
Polymorphism in the gene fk506 binding protein 5 (fkbp5) Involved in transcriptional regulation of the hpa axis (hypothalamic pituitary adrenal axis) Shown to interact with childhood abuse and trauma to predict stress- related psychopathology. Current study of paper: ge interaction effects may be related to variability in the threat related reactivity of the amygdala which plays a role in mediating physiological and behavioural adaptations to stress. Increased threat related amygdala reactivity may represent a mechanism linking psychopathology to interactions between common genetic variables affecting hpa axis function and childhood trauma. It"s a co-chaperone that mediates nuclear translocation of the cortisol- glucocorticoid receptor (gr) complex and gr-mediated gene transcription. Elevated fkbp5 levels confer reduced gr sensitivity to circulating cortisol, which leads to decreased negative feedback regulation of the. Hpa axis and a slower resolution of the stress response. Rodent research showed fkbp5 expression was linked to anxiety-ike behavior.
