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Lecture 3

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Western University
Kinesiology 2230A/B
Glen Belfry

Oct. 17 Lecture 3 - Partial pressure changes with barometric pressure Factors Affecting Exchange 1. Partial pressure gradient 2. Diffusion ajnd diffusion path length 3. Hb and Mb (myoglobin) concentration o Hb transport O2 to muscle, Mb picks up and transports within muscle cell o Mb is not just O2 carrier, stores it as well within muscle cell  Can be utilized within first few seconds in activity Gas Transported By Blood - Average male 14-18g Hb/100mL blood o Hematocrit: proportion of formed elements (Hb) to plasma - Avg female 12-16 Hb/100mL blood - 12 g Hb/100mL blood x 1.34 mL O2/g = 16 mL O2/100mL blood Concentrations of Hb and Mb as partial pressure changes - PP at about 100mmHg, as it drops 90-80-70 very little change in O2 bound Hb o Can go up in altitude (modestly), even though PP drops not going to see change in O2 bound Hb o Start to notice changes around 60mmHg PP, beings to drop  Every negative change in PP, going to see a large negative change in Hb saturation  PP drops and saturation changes, all oxygen is being dropped off at a tissue - PP can go much lower before noticing a big change in Mb concentration o Can have relatively low PP (40mmHg for ex.) and still have high Mb saturation (85%) o Need high affinity with Mb and oxygen because environment is always at a low PP anyways - Hb lower because you are using oxygen, which is picked up by Mb - Normal venous blood is between 40-100mmhg o Still have 70% saturation of Hb - Venous during exercise: PP is 10-40mmHg o Low saturation of Hb, still high saturation of Mb Altitude and Gas Expression - Gas expansion increases as altitude increases o 1L to 4L but still same number of O2 molecules, volume has increased therefore need to breathe more often to get same amount of O2 into blood O2 Saturation at Altitude - As altitude increases, PP decreases - Still delivering same amount of O2 to tissue Respiratory Changes at Altitude - As altitude increases, PPO2 is decreasing o There is a buffer zone, no changes in Hb saturation o Therefore no change in ventilation - Some point PPO2 drops, ventilation will increases but gas expansion happens at such a degree need to get more oxygen into the blood stream - PPCO2 decreases as altitude increases - Increase ventilation, breathing more often, producing sa
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