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Lecture 19

Exercise Nutrition - Lecture 19

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Kinesiology 3339A/B
Peter Lemon

KIN 3339AExercise Nutrition thLecture 19Wednesday October 26 2011 Omega 3 Fatty Acids and ObesityAn increase in omega3 fatslead to a decrease in body fat o In rodents and humansOmega3 fatty acids can regulate gene expression o Can activate a gene that regulates fat useGreater use of fat as a fuel o Lipogenic Enzymes that promote fat formationPromote formation of body fatOmega3 fatty acids in the diet down regulate these enzyme y Less formation of fat from the foods we eatDecrease in insulin sensitivity in the adipose cells o Insulin has different effects on different cellsFacilitates glucose movement INTO cells o Omega3 intake decreases the sensitivity of fat cells to insulin but increases the sensistivity of muscle cells to insulinPromotes uptake of glucose into the muscle to be used as fuelDont want glucose to enter the adipose cellsomega3 causes less glucose entry into the fat cellPromotes fat loss in the bodyLess fat formationmore glucose utilizationDoseresponse curve o Up to 1500 mg of omega3the maximum Lemon has ever used in his studies o Not sure if there is an upper limit to omega3 fatty acid intake ie the more you eat the more fat you will loseno evidence for this yetSome biochemical effects of omega3 intake o Related to the phospholipids in the cell membranes how they change Obesity ContinuedLipogenicfat formingLipolyticfat utilization o If we activate these kinds of enzymespreferentially use body fat for fuel o Lead to less body fatBetaoxidation is activated when you eat more omega3When you look in the mitochondrion where fast majority of the ATP is generated in the muscle cell
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