Kinesiology 4430F/G Lecture Notes - Lecture 8: Cardiac Muscle, Facilitated Diffusion, Membrane Transport Protein
20 Dec 2017
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Thought to only be a useless by-product not true. Important intermediate in buffering the cell, maintaining ph of cell, used as fuel, and liver uses it for gluconeogenesis: resting levels of lactate: 1mmol high level: 15mmol (seen in rowers) Muscle lactate production during exercise: pyruvate + 2h = lactate, pyruvate can be transferred to the mitochondria or, conversion of pyruvate to lactate lactate dehydrogenase (ldh, by accepting hydrogens, it regenerates nad for glycolysis. 2 isozymes: m-ldh (muscle) & h-ldh (heart: different functions, lactate released from muscle or taken up by muscle. Ldh controls the conversion of pyruvate to lactate. Can take on many different forms: 3 heterogeneous muscle subunits, 2 muscle, 2 heart subunits, 3 heterogeneous heart subunits, homogeneous forms of all muscle or all heart. Lactate metabolism during exercise: lactate is produced whenever there is a mismatch between pyruvate production and oxidation. Release and uptake of lactate in cardiac muscle. Movement in and out of the muscle cell.
