Kinesiology 2230A/B Lecture Notes - Lecture 4: Partial Pressure, Bohr Effect, Hemoglobin

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Published on 12 Apr 2013
Department
Professor
Lecture 4
Rowing
Rowers stop breathing when they pull back during rowing
Rowing rates dictates ventilation rates
Oxygen-Hemoglobin Dissociation Curve & Bohr Effect
Partial pressures drop at high altitude
Ventilation begins to increase, increase in partial pressures in the lung
As ventilation increases, partial pressures of carbon dioxide decreases
Affinity of hemoglobin to oxygen as partial pressure decreases
Saturation decreases less oxygen being delivered to the tissue
Oxyhemoglobin is less at any given partial pressure pH is low
o Low saturation
Hot weather oxygen delivery capacity reduced
o Will have to use anaerobic system, produce lactic acid
Low temperatures low partial pressure of oxygen offload oxygen at the tissue
Metabolic rate decreases with temperature
Buffers
More carbon dioxide than oxygen in the bloodstream
Hemoglobin carries oxygen AND carbon dioxide
H+ has a very high affinity to hemoglobin when the partial pressure of oxygen is low
o Carbonate released into the bloodstream
Metabolic carbon dioxide produced within the metabolic pathways (after pyruvate)
Non-metabolic increase in hydrogen ion concentration
Carbon dioxide accumulates = drop in pH In the blood = increase in H+
Carbon dioxide being produced at the muscle
VO2 max: RER > 1.5
ATP breakdown releases hydrogen
Hemoglobin manages the pH
Releases oxygen, picks up a hydrogen
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Document Summary

Rowers stop breathing when they pull back during rowing. Ventilation begins to increase, increase in partial pressures in the lung. As ventilation increases, partial pressures of carbon dioxide decreases. Affinity of hemoglobin to oxygen as partial pressure decreases. Saturation decreases less oxygen being delivered to the tissue. Oxyhemoglobin is less at any given partial pressure ph is low: low saturation. Hot weather oxygen delivery capacity reduced: will have to use anaerobic system, produce lactic acid. Low temperatures low partial pressure of oxygen offload oxygen at the tissue. More carbon dioxide than oxygen in the bloodstream. H+ has a very high affinity to hemoglobin when the partial pressure of oxygen is low: carbonate released into the bloodstream. Metabolic carbon dioxide produced within the metabolic pathways (after pyruvate) Non-metabolic increase in hydrogen ion concentration. Carbon dioxide accumulates = drop in ph in the blood = increase in h+ Carbon dioxide being produced at the muscle.

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