Microbiology and Immunology 2500A/B Lecture Notes - Lecture 5: Avian Influenza, Viral Envelope, Intracellular Parasite

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Take home: fundamentally, the proteins on viruses recognize proteins on host cells to initiate attachment and this results in viral entry which is sometimes followed by the releases of the viral genome at various subcellular locations. Attachment and entry: remove need to remove your shell and release your genome. Even though viruses are small, they are not small enough to be able to pass into the cell through passive diffusion and still require a cellular mechanism that allows them to enter the host cell. Viruses will have receptor specific recognition but the initial contact is random and through electrostatic interactions that occur all the time. This is not enough to trigger attachment and initiation of the infectious cycle unless there is specificity to this interaction. By definition, a resistant cell has no matching receptor receptor -cell recognition opens the door to the obligate intracellular parasite and leads to release of genome inside the host.

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