Microbiology and Immunology 2500A/B Lecture Notes - Lecture 35: Blastomyces Dermatitidis, Histoplasma, Genitourinary System
26 Jan 2017
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Document Summary
Usually starts in nose or paranasal sinuses, especially in debilitated patients with nasogastric tubes. One of the most rapidly spreading fungal infections. Have the ability to grow as both yeasts and molds, depending on the conditions. Acquired by the inhalation of airborne spores from soil. Technically, candida is dimorphic but is classified as a yeast since it causes infections and grows primarily in the yeast form. Penicillium marneffei is also thermally dimorphic but discussed in mold lecture. White cottony colonies which turn brown with age. At 37oc in brain, heart infusion broth with 10% sheep blood it forms small ovoid narrow based budding yeast cells. Acquired by inhalation of spores from soil heavily contaminated with bird or bat droppings. Usually self limited, but commonly causes scarring of the lungs which can present as. Can disseminate into reticuloendothelial system (liver, spleen, bone marrow) Yeast forms large double-walled, wide-based budding forms.
