Microbiology and Immunology 2500A/B Lecture Notes - Lecture 5: Natural Killer Cell, Interferon Type I, Interferon

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= ifn-a and ifn-b important antivirals rapidly secreted by virus-infected cells. Any nucleated cell can get infected with a virus. Secreted within 5 minutes of virus infection: type i ifns activate natural killer cells. Every activated nucleated cell in body (not rbc) secrete cytokines (how cells talk to eachother) Chemokines attract nk cells: type i ifns activates uninfected cells to produce antiviral enzymes to protect themselves from viral infection. These enzymes inhibit viral replication, which limits viral spread. So when they bind interferon receptor they produce these antiviral enzymes. Type i ifn is used clinically to treat certain viral infections interferon. Hepatitis c- within last decade, hep c mutated so it became resistant to type 1. 2-4% of global pop has hep c so this is a problem all large pharmaceutical companies started new treatment searches for hep c billion dollar industry. Some viruses block ifn production by its infected cell to evade innate immunity rely on t cell immunity.

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