Microbiology and Immunology 2500A/B Lecture Notes - Lecture 12: Epitope, Hypogammaglobulinemia, Antiparasitic

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Antigens: lipids & polysaccharides (e. g. lps, bacterial capsules) With b cell response to non-protein a(cid:374)tige(cid:374)s, it does(cid:374)"t (cid:396)e(cid:395)ui(cid:396)e help of t helpe(cid:396) folli(cid:272)ula(cid:396) (cid:272)ell. Non protein binds to b cell receptor and stimulates activation signal way stronger that proteins that can drive clonal expansion. If p(cid:396)otei(cid:374)s, (cid:272)ould(cid:374)"t d(cid:396)i(cid:448)e (cid:272)lo(cid:374)al e(cid:454)pa(cid:374)sio(cid:374) (cid:449)ith a(cid:272)ti(cid:448)atio(cid:374) sig(cid:374)al. But tradeoff is you only will generate short-lived plasma cells (low affinity) no memory b cells. In response to polysaccharide: when b (cid:272)ell that"s spe(cid:272)ifi(cid:272) to pol(cid:455)sa(cid:272)(cid:272)ha(cid:396)ide, (cid:374)ot st(cid:396)o(cid:374)g e(cid:374)ough, (cid:374)eed (cid:373)e(cid:373)o(cid:396)(cid:455) Generally not secreted as antibody absent or extremely low levels in blood. Ab function is unknown: most remains bound to na ve b cells. Most infections are in tissues, not systemic so this is ineffective. Most abundant antibody in blood and tissues provides passive immunity to newborn: only isotope that can cross placenta and enter fetus maternal igg is the only isotype capable of crossing the placenta.

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