Microbiology and Immunology 2500A/B Lecture Notes - Lecture 8: Virulence-Related Outer Membrane Protein Family, Deet, Overdiagnosis
28 Feb 2018
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Document Summary
Gram negative spirochete thin (~0. 5 m) and long (>10 m), spiral shaped. Reservoir for borrelia burgdorferi: burgdorferi is transmitted to different mammalian hosts through ticks, burgdorderi is only found in their vertebrate or arthropod hosts. Ixodes tick (black legged or deer tick) hard bodied ticks. In north america, b. burgdorferi is transmitted primarily by ixodes scapularis (east cost) and ixodes pacifica (west cost) other species transmit in europe and asia. 3 stages: larva nymph adult ticks require blood meals between stages no adult to egg transmission ticks must acquire b. burgdorferi. Must get infected through mammal host, cant pass on to eggs. Mice, squirrels and birds can carry b. burgdorferi. Majority of human infections come from nymphs: most of transmission from nymphs cause smaller and hard to see (can happen in adults tho) Early localized stage occurs ~1-2 weeks after tick bite.
