Microbiology and Immunology 2500A/B Lecture Notes - Lecture 20: Mycobacterium Bovis, Gram Staining, Intracellular Parasite
15 Mar 2018
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Global incidence per 100,000: even low incidence countries like canada still present. Innate system will try to chew up tb but it actually wants to be in there it can multiply there. Tuberculosis: around 75% of active tuberculosis is pulmonary, progressive, irreversible lung destruction can occur, and the bacteria may enter the bloodstream. If positive careful history (vaccination), and chest x-ray (will show upper lobe (cid:862)shado(cid:449)i(cid:374)g(cid:863) (cid:449)hi(cid:272)h are lesio(cid:374)s(cid:895: could also show calcified granulomas, staining of sputum for acid fast bacilli, culturing, more complex stuff. Treatment: short treatment: six months of antibiotics, slow growth = takes a long time to kill, multiple types of antibiotics are used, rifampin inhibits rna poly, others . Isoniazid inhibits mycolic acid synthesis: why multiple drugs, combat resistance think of that video we watched. Immunocompromised with hiv = more likely to get it and die from it !
