Microbiology and Immunology 2500A/B Lecture Notes - Lecture 2: Inflammatory Bowel Disease, Innate Immune System, Tight Junction

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Innate immunity is the first line of defense. They have barriers which block pathogen entry and innate cells which rapidly eliminate pathogens that enter tissues. Innate immunity is always ready to destroy pathogen at an early stage. If for some reason innate immunity is unsuccessful then adaptive immunity will help eliminate the problem. There are 4 modes in which a pathogen can enter the body (barriers: respiratory tract, gi tract, broken skin, urogenital tract/urinary tract. These are all halted by epithelial cells which prevent pathogen entry. Epithelial cells: cells that form tight junctions, are rapidly renewable, shed (desquamation), and secrete antimicrobial peptides called defensins. Efflux of nutrients, essential ions and ore flow out of the microbe. Influx of water from the extracellular environment flows into the microbe. An inflammatory bowel disease in which the intestinal epithelial cell tight junctions are ineffective. Fatty acids and low ph are unfavourable conditions for viruses to survive.

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