Microbiology and Immunology 2500A/B Lecture : Plague

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Incubation of 2-6 days, death in about 2-4 days. Patients experience sudden onset of fever, chills, headaches, muscle pain, weakness. Painful swellings (buboes) of the lymph nodes in the armpits, legs, neck, or groin. High fever, delirium and mental deterioration, large blackish pustules that burst, vomiting of blood, bleeding in the lungs. Discovered independently by alexandre yersin and shibasaburo kitasato in 1894. Pestis pestilence (contagious or infectious epidemic disease) Causes death in 2-4 days by sepsis and/or overwhelming pneumonia with respiratory failure. Samples of teeth from the bodies that carried the plague were taken dna was extracted from the teeth of these victims. Genome of y. pestis was sequenced from teeth thus, y. pestis did cause the black death. Organisms live in rodents and are transmitted by fleas. A zoonotic pathogen diseases that are transferred from animals to humans are known as zoonotic pathogens. Y. pestis causes blocking in the flea.

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