Microbiology and Immunology 3100A Lecture Notes - Lecture 5: Golgi Apparatus, Secretion, Protein Targeting
19 Apr 2020
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Transport between rer and cis-golgi (dxe, kdel and kkxx protein sorting signals) Trafficking from trans-golgi network to lysosomes (m6p sorting signal) Chapter 14: vesicular traffic, secretion (intro) p. 632-634, (molecular mechanisms of vesicular traffic) p. 638-648, (early states of secretory pathway, copi & copii vesicles, later stages of secretory pathway) p. 651- Now we want to go from rer to the golgi apparatus. Ultimately, these sequence of events from rer to golgi are through secretory vesicles. Overview of secretory and endocytic pathways of protein sorting. Some proteins that make it to the top part of the golgi complex will be secreted or sorted towards lysosomes. Proteins and organelles outlive their function and need to be degraded. Lysosomes contain digestive enzymes (hydrolases) & are very important for breaking down potentially problematic proteins or organelles. If that doesn"t happen you could have a number of serious diseases. This lecture is talking about how proteins made in rer go to the golgi complex.
