Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Toxic Shock Syndrome, Fibronectin, Folliculitis
Document Summary
So (cid:272)ultu(cid:396)e does(cid:374)"t get destroyed on hot days: staphylococcus aureus. Id by colonial (cluster of grapes) and gram stain (gram positive = violet: *** coagulase positive (almost all other staph bacteria are coagulase negative). Virulence factors: cell wall virulence factors, protein a which binds to the fc portion of igg and inhibits phagocytosis, fibronectin-binding protein (fnbp, fibronectin: cold soluble globulin coagulate in cold and dissipate in hot. Produce elastase cleaves fibronectin off the mucosa: hospital-acquired pneumonia: elastase goes up fibronectin cleaved off. Gram-neg rod bacteria are able to bind the mucosa colonize both. Gram-neg and s. aureus get both vomiting and diarrhea: membrane damaging exotoxins, , ,(cid:630),(cid:631) and leucocidin, exotoxins: protein toxins that are pumped out of living cells into the environment. Very powerful: leucocidin = kill white blood cells (-ciding = killing, superantigen exotoxins, these protein toxins have an affinity for a relatively high conserved region of the t cell receptor, the mhc class ii complex.