Microbiology and Immunology 3820A Lecture 4: Lecture 4 Study Note MICRO

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Lecture 4 study note b cell (humoral) immunity. Describe how antibodies function to remove or neutralize pathogens. Describe the kinetics of antibody production following primary exposure vs. re-exposure to a protein vs. non-protein antigen. What b cell components provide long term immune protection. Some of these clonal cells differentiate into plasma cells which secrete antibodies with identical antigen specificity to the b cell receptor that first recognized the antigen. Secreted antibodies have several functions including: binding to antigen on microbes in order to neutralize them, activation of the complement system, opsonisation (coating) of pathogens to target them for phagocytosis. Length: class is defined by differences in heavy chain constant region (variable region on the end), distribution of carbohydrates (grey hexagon) Location of hinges (disulphide bonds: gives mobility and flexibility, e. g igg molecule is able to flex and bind to epitope much better & with a stronger bond as it has 2 hinges.

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