Medical Biophysics 3503G Lecture Notes - Lecture 5: Precancerous Condition, Overdiagnosis, Rare Disease

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One was excellent detection accuracy and one was merely good detection accuracy. We had observed that if you go from the merely good to the excellent system, it would improve the maximum utility that you could get from screening mammography. The exact improvement was from a maximum utility of. 3 (merely good) to a maximum utility of 4 (excellent); a factor of 4/3. If we take the point of view from the other side of the debate: point of view of people who are concerned about overdiagnosis. So we must make adjustments of the utilities; make the utility of true positive smaller and utility of false negatives less negative. Overdiagnosis: overdiagnosis would reduce u(tp, u(tp) must be weighted average (based on what we think the fractions of each section is) of: Benefit to patients whose lives are saved (last at least 5 years past the date of diagnosis) Benefit to patients whose lives are prolonged.

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