Medical Sciences 3999A/B/Y Lecture Notes - Lecture 2: Phagocytosis, Lipid Raft, Membrane Potential
2 Feb 2020
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Lecture 2 - introduction to the cell plasma membrane. Eukaryotes: genetic material in nucleus: jansen: associated with inventing the first telescope. 4 types of tissues: epithelial, muscular, connective, and nervous tissue. At high concentrations, the prevent phospholipids from crystallizing together (thereby prevents extreme firmness or extreme fluidity and maintains the consistency of the cell) Lipid rafts: localized regions in the membrane with high concentrations of cholesterol and glycosphingolipids. Thicker and less fluid than the surrounding plasma membrane. Contains integral and peripheral proteins for signalling functions. Integral proteins pass through the membrane (may be single-pass or multi-pass) Functions: pumps, channels, receptors, linkers, enzymes and structural proteins. Peripheral proteins are on the ec side of the cell, and bound to lipids non-covalently. Lipid-anchored proteins are peripheral proteins that are bound to lipids covalently. Glycocalyx: 10-20 nm coating on the external surface of the cell membrane. Function in cell metabolism, recognition, cell-cell associations (adhesions), and as receptors.
