Medical Sciences 3999A/B/Y Lecture 3: (HSTL 1102 - Block-1)
2 Feb 2020
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High protein content and microfilaments --> changes consistency to gel-like. Non-membraneous organelles: ribosomes, centrioles, cytoskeleton, cilia/microvili, inclusions, etc. Mitochondria: aerobic respiration to make atp; have their own nucleated dna (endosymbiotic theory) *highly present in liver, kidney tubules, axon terminals, muscles, parietal cells, neuro-muscular junctions, and sperm. These locations require atp for active transport (i. e. kidney tubules and parietal cells require h+ ions to be pumped in, etc. ) Two types of cristae depending on cell type and function: Tubular-like: steroid secreting cells(e. g. adrenal cells, gonadal cells) In the mitochondrial matrix --> uses citrate to recycle nadh and fadh2. *brown adipose tissues have thermogenin in the inner membrane of the mitochondria. Mitochondria is maternally inherited - all disorders are associated with damaged maternal mitochondrial dna (paternal contribution in the sperm is the nucleus only; mitochondria is only used for flagellar motion of the sperm and is eventually lost). Defects primarily affect muscles and neurons which are highly dependent on mitochondrial atp.
