Medical Sciences 4930F/G Lecture Notes - Lecture 4: Molecular Imaging, Streptozotocin, Snap25

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Medical science 4931g lecture 4 molecular mechanisms and imaging: islet cell biology. In this section we are going to discuss islet architecture, cell biology of insulin synthesis and secretion, cell biology of glucagon synthesis and secretion, and changes in islet mass in diabetes. We will also learn about the ways that islets can be detected using different imaging modalities: look at the image below of islets from mice and humans. Take a minute and write down similarities and differences based on the images: mouse is usually a model (single islet, cells in green are insulin producing cells, primarily in the islet, cells in red are glucagon producing cells. The image below outlines the steps of how the beta cell makes bioactive insulin. 6. 0: when it fuses with the plasma membrane, and releases the cargo into the circulation, the ph goes up to 7. 4.

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