Microbiology and Immunology 2500A/B Lecture Notes - Adaptive Immune System, Mannose, Innate Immune System
19 Apr 2013
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Document Summary
Properties of innate immunity: inherited from parents you are born with it. Everyone has the same innate defenses = well conserved in evolution: as vertebrates, we also have adaptive immunity, always initiated when pathogen contacts body, responds immediately to pathogen, no memory. Adaptive immunity remembers pathogen innate doesn"t remember same immune response to identical pathogen with each exposure = non-adaptive innate immune defenses: barriers block pathogen entry into tissues (first line of defense) Modes of pathogen entry into the body: Respiratory tract (breathing) you inhale into lungs. Skin (wound) - injured skin ex, you cut yourself or get a hangnail. Gastrointestinal tract (ingestion) - digestive system gi tract ex, eat contaminated food (food poisoning) Main barrier that prevents pathogen entry = epithelial cells (endothelial cells line blood vessels) Gal bladder simple columnar epithelial cells. Bladder hard for pathogen to break through. Ex, coughing, sneezing, vomiting, diarrhea, tears (has enzymes), saliva (has enzymes)
