Microbiology and Immunology 2500A/B Lecture Notes - Lecture 29: Bovine Spongiform Encephalopathy, Transmissible Spongiform Encephalopathy, Chronic Wasting Disease
15 Mar 2018
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Document Summary
Transmissible spongiform encephalopathies (tses: scrapie, bovine spongiform encephalopathy (bse) mad cow disease, creutzfeldt-jakob disease (cjd) human form, kuru another human form, chronic wasting disease (cwd) Long pre-clinical period most cases is years: personality changes, psychiatric problems such as depression, patients may also experience involuntary jerking movements, unusual sensations, insomnia, Lack of coordination and/or unsteady gait confusion, or memory problems: fatal familial insomnia is an i(cid:374)herited for(cid:373) (cid:449)here the(cid:455) (cid:272)a(cid:374)"t sleep a(cid:374)d the(cid:455) are a(cid:449)ake until they die. In the later stages of the disease, patients have severe mental impairment and lose the ability to move or speak: after the onset of symptoms, death can occur within months to years. Prion diseases can be infectious heritable and sporadic: prpsc can be infectious, prp is encoded by the prnp gene, mutated prnp can induce tses and can be heritable. Efficiency of transmission for prions: most efficient least efficient. Injecting protein directly into brain most infectious (animal model.
