Microbiology and Immunology 3300B Lecture Notes - Lecture 6: Resolvin, Uric Acid, Mhc Class I
3 Mar 2018
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Document Summary
Whenever you get splinter in finger deposits bacteria in body can amount inflammatory response to any pathogens that are coming in to body: can be local response (i. e. pimple, systemic response. Acute inflammatory (resolved after few days) or chronic long-term. Generally, considered innate immune response: but also important in developing adaptive immunity. We all had some signs of inflammation before. Have tissue and postcapillayr venule (all lined by endothelium) Venules and capillaries allow transportation of immune cells and plasma around the body. Immune cells across endothelium migrate to source of pathogenic insult start phagocytosis, etc. to get rid of infection (what is happening at the local site) When dc takes up antigen activated migrate to local draining lymph node present to t cell. Tissue damage; alarmins: even trauma itself like cutting your skin can cause tissue damage, tissue damage release alarmins (alert immune system to something not being right).
