Microbiology and Immunology 3300B Lecture Notes - Cfu-Gemm, Pattern Recognition Receptor, Nadph Oxidase
18 Oct 2013
School
Department
Professor
Document Summary
Lecture 3 objectives: learn the mechanisms of innate self/non-self recognition. Lecture 3: cells and effectors ii: self-recognition receptors, examples of pamps, learn the origin, circulation, morphology and function of myeloid immune cells. Other mechanisms of innate self-recognition: sialic acid, glycosaminoglycans, mhc-binding receptors. Pattern recognition receptor (prrs: germ-line encoded receptors, bind evolutionarily-conserved pathogen molecules. Regulated by germ-line encoded receptors which recognize: self other germ-line encoded proteins, or carbohydrate moieties not found in pathogens, non-self evolutionarily conserved pathogen molecules. Monocytes released from bone marrow and go into blood, and get recruited into tissues where they. In peripheral tissue, monocytes differentiate into macrophage turn into tissue-specific macrophages. Equipped to very quickly respond to pathogens; once differentiated into macrophages, more like a vacuum cleaner in the body. Name varies by tissue: liver = kupffer cells, brain = microgilia, lungs = alveolar m . Most abundant immune cells in the blood (50-60%)
