Immunology Notes

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Microbiology and Immunology
Microbiology and Immunology 3300B
Rodney Dekoter

Immunology NotesOct 612 Complement Heatlabile component of plasma that complements killing of bacteria by antibodies both plasma and serum contain complement components It participates in both innate and adaptive immune responses It is a large number of proteins 48 that interact in a hublike network as well as with other systems The function of complement proteins is to opsonize pathogens to combat infection Opsonization is when pathogens are irreversibly marked to be targeted for destruction by the immune system Proteins in several complement pathways function as zymogens which are proteases that themselves have to be activated by other proteases The three major pathways of complement activation are classical pathway bridge between adaptive and innate because it needs antigen lectin innate and alternative innate Zymogens are good because it means that these pathways wont be activated until other things are active and it allows for amplification of complement cascade IgM is efficient at activating the classical pathway of complement IgG3 and IgG1 are good and IgG2 is ok Nomenclature for the complement system C designates proteins belonging to the classical pathway Number designates the name of the component Number is in order of discovery not activation Products of cleavage reactions are designated by adding a lower case letter as a suffix The classical pathway Is initiated by pathogen sensor complex C1 which is composed of C1q C1r and C1s C1q is composed of six identical subunits with globular heads and long tails The tails interact with C1r and C1s The heads interact with IgM or IgG to initiate complement fixation pathway by causing a conformational change in C1r which then cleaves and activates the C1s zymogen IgC1q interactions in the classical pathway The classical pathway is initiated by the binding of C1q to antibody on a pathogen surface A pentameric IgM molecule
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