Immunology Notes

3 Pages
Unlock Document

Microbiology and Immunology
Microbiology and Immunology 3300B
Rodney Dekoter

Immunology NotesSept 2712 Inflammation is an innate immune response characterized by the accumulation of fluid plasma proteins and immune cells at the site of tissue damage or infection It has local and system effects can be acute or chronic and is generally considered an innate immune response Cardinal signs of inflammation calor heat dolor pain rubor redness tumor swelling functio laesa loss of function The postcapillary venule is where cell recruitment takes place The endothelium does not contain any tight junctions so there is some leaking When cells detect pathogens they secrete cytokines telling the endothelial cells to recruit immune cells They flow from the blood into the tissue and attack the pathogen Inflammation overview 1 Initial detection of pathogen or tissue damage 2 Local production of proinflammatory cytokines 3 Initiation of recruitment cascade 4 Recruitment of inflammatory cells and plasma proteins 5 Induction of systemic effects 6 Induction of adaptive immunity 7 Resolution turn off response allow cell to heal 1 Detection of pathogens and tissue damage Pathogens are detected by PRRs Tissues damage not associated with bacteria can release DAMPs such as mitochondria fMLP DNA CpG intracellular proteins HMGB1 HSP70 metabolites ATPP2YP2X uric acid These are cytosolic or nuclear and are released when theres damage and bind to TLRs Detection of pathogens Macrophages have phagocytic receptors that bind microbes and their components
More Less

Related notes for Microbiology and Immunology 3300B

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.