Microbiology and Immunology 3300B Lecture : Immunology Notes
20 Feb 2012
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Document Summary
Inflammation is an innate immune response characterized by the accumulation of fluid, plasma proteins, and immune cells at the site of tissue damage or infection. It has local and system effects, can be acute or chronic, and is generally considered an innate immune response. Cardinal signs of inflammation: calor (heat), dolor (pain), rubor (redness), tumor (swelling), functio laesa (loss of function). The postcapillary venule is where cell recruitment takes place. The endothelium does not contain any tight junctions, so there is some leaking. When cells detect pathogens, they secrete cytokines, telling the endothelial cells to recruit immune cells. They flow from the blood into the tissue and attack the pathogen. Tissues damage not associated with bacteria can release damps, such as mitochondria, fmlp, dna (cpg), intracellular proteins (hmgb1, hsp70), metabolites (atp p2y/p2x, uric acid). These are cytosolic or nuclear and are released when there s damage and bind to tlrs.
