Immunology Notes

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Department
Microbiology and Immunology
Course
Microbiology and Immunology 3300B
Professor
Rodney Dekoter
Semester
Fall

Description
Immunology NotesSept 2712 Inflammation is an innate immune response characterized by the accumulation of fluid plasma proteins and immune cells at the site of tissue damage or infection It has local and system effects can be acute or chronic and is generally considered an innate immune response Cardinal signs of inflammation calor heat dolor pain rubor redness tumor swelling functio laesa loss of function The postcapillary venule is where cell recruitment takes place The endothelium does not contain any tight junctions so there is some leaking When cells detect pathogens they secrete cytokines telling the endothelial cells to recruit immune cells They flow from the blood into the tissue and attack the pathogen Inflammation overview 1 Initial detection of pathogen or tissue damage 2 Local production of proinflammatory cytokines 3 Initiation of recruitment cascade 4 Recruitment of inflammatory cells and plasma proteins 5 Induction of systemic effects 6 Induction of adaptive immunity 7 Resolution turn off response allow cell to heal 1 Detection of pathogens and tissue damage Pathogens are detected by PRRs Tissues damage not associated with bacteria can release DAMPs such as mitochondria fMLP DNA CpG intracellular proteins HMGB1 HSP70 metabolites ATPP2YP2X uric acid These are cytosolic or nuclear and are released when theres damage and bind to TLRs Detection of pathogens Macrophages have phagocytic receptors that bind microbes and their components
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