Immunology Notes

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Microbiology and Immunology
Microbiology and Immunology 3300B
Rodney Dekoter

Immunology NotesOct 1812 MHC class II molecules have an open conformation where longer peptides can fit They are made ofandchains made of two genes and each gene has two alleles and there are many different alleles possible The 2 and 2 domains are transmembrane domains The peptidebinding cleft is made of the 1 and 1 domains but they are not joined by a covalent bond The peptidebinding groove is open at both ends Peptide binding to MHC class II molecules is stabilized by numerous contact points They bind all along the length of the binding groove not just at the ends like class I There are hydrophobic or hydrophilic interactions and hydrogen bonds between the peptide and the MHC molecule The average peptide binding to class II molecules is 1317 amino acid residues length is not constrained The ends are unimportant for peptideprotein contact Anchor residues or contact points lie at various distances from the ends of the peptide The location is different for every class II molecule In class I anchors are in specific locations Peptides in common will have similar anchor residues The structure of CD4 and CD8 coreceptors The CD4 molecule contains four Iglike domains D1 D2 D3 D4 D1 and D2 are linked to D3 and D4 by a flexible link The binding site for MHC class II molecules involves mainly the D1 domain It is transmembrane The CD8 molecule is made of two separate proteinsandis a heterodimer covalently linked by a disulphide bond Both are transmembrane T cells will be either CD4 or CD8 This will determine what antigen presenting cell the T cell can interact with As T cells are developing they become either CD4 or CD8 T cells are distinguished by the expression of the cellsurface proteins CD4 and CD8 How do CD4 and CD8 T cells interact with antigenpresenting cells expressing class I and II MHC moleculesD1 and D2 of CD4 binds with 1 and 2 of MHC class II It forms a tight but noncovalent interaction that is weak Thedomain of CD8 molecules interacts
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