Immunology Notes

3 Pages
Unlock Document

Microbiology and Immunology
Microbiology and Immunology 3300B
Rodney Dekoter

Immunology NotesOct 20 What are the consequences of not having an adaptive immune systemcase studybay joe He had decreased numbers of white blood cells lymphocytes T cellsand B cells and increased numbers of NK cells He had a frameshift mutation in both Rag genes Mutations in the B cell developmental pathway cause many problems such as SCID Severe combined immunodeficiency SCID is the absence of adaptive immunity and is the most severe of the primary immunodeficiency diseases It is classified by detection of T B and NK cellsT B NK most severe formall absent T B NK most common form T B NKT B NK form present in case studyCaused by Rag mutation affects both T and B cell development because Rag is needed for VDJ recombination David Vetter bubble boy had SCID Development of common lymphocyte progenitor cells early stages All immune cells and blood cells are generated from hematopoietic stem cells These generate lymphocytes through the generation of multipotent progenitor cells MPP then the common lymphocyte progenitor CLP CLP leads to the generation of pre B T and NK cells which form the mature cell types Lymphoid progenitor cells Derived from the hematopoietic stem cell Progeny are progenitor B cells progenitor T cells and NK cells Proliferationdifferentiation is regulated by transcription factors and cytokinescytokine receptors Stem cell to common lymphoid progenitor to proB proNK proT to B lymphocyte NK cell T lymphocyte Cytokinesreceptors involved in early lymphocyte development Interleukin7 IL7 Flt3 ligand FL and stem cell factor SCF are important for the survival and proliferation of early developing progenitors IL7 promotes survival proliferation and differentiation Il7 FL and SCF are low MW soluble proteins produced by stromal cells in the bone marrow and by other cell
More Less

Related notes for Microbiology and Immunology 3300B

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.