Immunology Notes

3 Pages
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Department
Microbiology and Immunology
Course Code
Microbiology and Immunology 3300B
Professor
Rodney Dekoter

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Immunology NotesOct 2512 The TCR has many similarities to the BCRAb and looks like a Fab fragment It hasandchains each with two Ig domains V and C regions and CDR1 CDR2 and CDR3 in the V region Signalling is mediated through a molecular complex that includes CD3 contains twodomains onedomain and onedomain and achain with ITAM on them CDR1 and CDR2 are found in the periphery and recognize MHC CDR3 is highly variable and is found in the centre of the TCR and interacts with antigen TCRpeptideMHC binding Involves a large complex of molecules The coreceptors CD4 or CD8 and TCR bind to peptideMHC complexes on the surface of antigenpresenting cells This leads to the recruitment of Lck which phosphorylates the ITAMs on CD3 andin the TCR ZAP70 binds to phosphorylated ITAMs through its SH2 domain which causes it to be phosphorylated by Lck Assembly of this complex initiates signalling This sets off a cascade of events in the cell that eventually leads to T cell proliferation and differentiation Thymic development of T lymphocytes starts in the bone marrow from the production of the common lymphocyte progenitor but then must be recruited to the thymus The thymus creates an environment that is necessary for T cell differentiation A thymectomy or nude micedigeorge syndrome causes no T cell to develop This shows that the thymus is critical for the maturation of bone marrow derived cells into T cells At different stages of differentiation and development T cells undergo migration or shifts in location and are found in different parts of the thymus The earliest precursor thymocytes enter the thymus from the bloodstream via venules near the corticomedullary junction As the cells differentiate through the double negative DN stages they migrate up to the cortex and then to the subcapsular region As they become double positive cells they migrate back down to the medulla The medulla c
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