Microbiology and Immunology 3300B Lecture : Immunology Notes
20 Feb 2012
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Document Summary
Inflammation may cause cancer: many chronic inflammatory diseases increase the risk of cancer at the site of inflammation. Reactive oxygen and nitrogen species (ros/ron) can mutate dna. Ros (immune system product) can generate many mutated dna bases. Inflammation, infection, and cancer: chronic inflammation (infection or other) can lead to cancer. An example is the bacteria helicobacter pylori, which causes stomach ulcers. Examples are epstein-barr virus, kaposi s sarcoma virus, human papilloma virus (hpv). Infections may cause up to 25% of all cancers. Vaccination against these viruses can prevent these cancers. Cervical cancer and hpv: cervical cancer is the 5th most common cancer in women. Hpv-16, hpv-18, hpv-6, and hpv-11 cause 90% of all cervical cancers. Hpv vaccines: guardacil protects against hpv-16, hpv-18, hpv-6, and hpv-11. It consists of empty (no genome, just protein) virus particles containing hpv proteins. It consists of l1 capsular protein from each serotype plus alum as an adjuvant.
