Microbiology and Immunology 3300B Lecture : Immunology Notes

65 views3 pages

Document Summary

Autoimmune diseases: broadly classified as systemic or organ-specific. It is possible to have more than one disease. Systemic autoimmunity: rheumatoid arthritis is a type iii hypersensitivity immune complex- mediated disease. The autoantigen involved is rheumatoid factor igg complexes. Rheumatoid factor is an autoantibody (antibody directed against one s own tissues). Rf and igg join (at fc portion) to form immune complexes. Rf is an antibody against an antibody complex. 90% of patients with rheumatoid arthritis have the autoantigen igg (rf). Autoantigens in sle (lupus): dna autoantigens involved are dsdna, ssdna, histones. Rna autoantigens involved are sm, snrnp, ro (ss-a), la (ss-b). Systemic lupus erythematosus (sle): is a type iii hypersensitivity immune complex-mediated disease. The immune complexes become deposited on small blood vessel walls, and they are pro- inflammatory. Tissues affected are kidneys, skin, muscles, joints, lungs, heart, brain. Results in cell destruction (complement or fcr) and alteration of signalling or function (receptor blockade or activation).

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions